It was a small group of people (it tends to be with these endocrine disorders unless it's retrospective), so hopefully someone will do one with even more Adult Growth Hormone Deficiency subjects and thus more data (retrospective is fine by me!). Even so, get a load of this:
Current thinking is that Growth Hormone Replacement Therapy (GHRT above) can cause or exacerbate diabetes. This suggests it might actually help cure it. I don't officially have diabetes, but I've been watching my sugars every so often for a couple years (it can help you track your symptoms and know when to test for cyclic Cushing's Disease). My post-meals are always fine, but my fasting has been creeping to the top of the range. Hopefully GHRT will not only reverse that trend, but make it possible for me to be more active and start cooking again! (Not staking too much hope on that one, am I?)ResultsFollow-up ranged 2-84 months (mean 21 months). The mean age of the patients was 50.2yr (range 28-77yr). The mean dosage of GH replacement was 0.21mg/day (range 0.1-0.4mg/day). The value of HbA1c during the replacement in non-diabetic patients was not significantly changed and no one developed type 2 diabetes. On the contrary, glycemic control in diabetic patients has been dramatically improved. In addition, liver dysfunction due to fatty liver was concomitantly improved and their body weights also decreased by GHRT. One of the cases of diabetic patients will be presented. In brief, a 44-year-old man was referred to our hospital presenting with fatigue and hyperglycemia. On admission, he was diagnosed as type 2 diabetes with HbA1c value of 11.5% and severe aGHD. Together with diet for diabetes, GHRT was commenced. His glycemic control was dramatically improved with a reduction of HbA1c value from 11.5% to 5.5% by GHRT for 3 months. HbA1c has been maintained around 5.5% for more than one year without any antidiabetic drugs. HOMA-IR was 1.76 on admission and decreased down to 1.04 one year later, indicating that his insulin resistance was apparently improved by the treatment.